For thousands of years, medicinal mushrooms have been widely used to help strengthen the immune system and fight off colds and flu in humans. In particular, Eastern medicine practitioners have known of the healing and regenerating properties of mushrooms for millennia.

As a result, medicinal mushrooms are receiving more mainstream attention as a powerful tool in boosting immune defense, giving you the edge you need to bounce back when you do get sick.

1. Medicinal mushrooms can stimulate & modulate immune cells and processes

Medicinal mushrooms can help with your body’s immune response by working to strengthen and support its natural defense processes.

It’s well established that medicinal mushrooms are effective immune system modulators and immune cell activators. These fungi have a direct impact on your body’s production and use of Natural Killer cells, T cells, B cells, antibodies, macrophages, and cytokines. These cells are all part of the immune system and play a role in your body’s ability to fight off infection.

Two immune systems in the human body

For example, the medicinal compounds of certain mushroom varieties are known to modify cytokines, which are both pro and anti-inflammatory messengers secreted by immune cells. Certain cytokines can suppress white blood cells and make you more susceptible to getting sick. However, mushrooms can help to reduce the inflammatory response caused by cytokines and allow for T cells, B cells, and antibodies to work more effectively.

There are many studies showing that mushrooms can stimulate or suppress different anti-inflammatory and pro-inflammatory cytokines. Immunomodulation is the ability of the body’s immune system to respond intelligently to any biological circumstances in the body:

“Mushrooms can increase inflammatory cytokines in the start of an infection (which is what you actually need to fight off a virus naturally) but then are extremely anti-inflammatory in the second half. Herbs and mushrooms are immune modulators, meaning they can adjust how they are affecting the body based on need in the moment.”

– Dr Mark Greg Iwanicki ND

Scientific evidence (in vitro) also suggests that active compounds in mushrooms may play a role in influenza viral modulation by inhibiting the enzymes viruses use for replication. This mechanism is the basis for most antiviral drugs.

2. Key Compounds in Mushrooms: Polysaccharides and Beta-glucan


Mushrooms are rich in bioactive compounds called polysaccharides, including beta-glucans, which act as biological response modifiers.

The innate immune system identifies infections through pattern recognition receptors (PRRs), and these receptors recognize molecular patterns of specific infection molecules. Polysaccharides such as beta-glucans cannot enter cells due to their large size. Instead, these cells and their metabolites bind to recognition receptors on other cells, thereby helping the body recognize and strengthen the immune system. Beta-glucans are recognized by the immune system as “non-autologous molecules”, stimulating innate and adaptive immune responses and providing protection from the attack of certain pathogens. .

Well-researched mushroom varieties that can help to boost the innate and adaptive immune systems include Reishi, Turkey Tail, Chaga, Shiitake, Cordyceps, and Maitake.

By understanding the role medicinal mushrooms play in boosting the immune system, you can make more informed choices about foods and supplements for the body. The benefits of medicinal mushrooms on general health and immune function are proven and supported by considerable scientific evidence and practiced for thousands of years in Eastern medicine.

3. Where to buy Reishi mushrooms  to strengthen the immune system?

With its outstanding use and reasonable price, Reishi mushroom is a smart choice for you and your family to use to strengthen the immune system effectively. Choose Reishi mushroom products that ensure origin and quality to ensure your health and your family’s health!

Red Reishi mushroom in PLN Mushroom ensures origin and quality

Pham Le Nguyen one member limited liability company- Proud to be a supplier of high quality MEDICAL MUSHROOMS, ensuring the CLEAN – SAFE – MULTIPLE PHARMACEUTICAL SUBSTANCES criteria, in accordance with Vietnamese organic standards. Pham Le Nguyen Mushroom provides not only high quality Red Reishi Mushroom, but also guidance for use and enthusiastic advice from an experienced team of the company.

You can find and buy Red Reishi mushroom products here